The sceptical chymist posted a short interview with Nadrian Seeman today, which reminded me of my DNA-richer days, long ago they seem. If you remember my last comment on DNA-Polymer conjugates you know that DNA can do all sorts of nice things for polymer chemists as well as material scientists. But there is more than that.
Nadrian Seeman’s work has been a source of awe and inspiration for quite some time. I don’t really want to give too much away, but rather show some nice concepts and pictures from the general area of DNA-based structures and materials. Check them out or take a look at some of the following reviews:
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- Seeman2002
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Emulating biology: Building nanostructures from the bottom up
Seeman, N. C. and Belcher, A. M.
Proceedings of the National Academy of Sciences 99 6451-6455 (2002)
10.1073/pnas.221458298
- Storhoff1999
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Programmed Materials Synthesis with DNA
Storhoff, J. J. and Mirkin, C. A.
Chem. Rev. 99 1849-1862 (1999)
10.1021/cr970071p
And here some neat examples of DNA-toy-structures: Note that the trend seems to go to structures that are either self-assembled (utilizing the inherent programmable structure of DNA) or resemble macroscopic structures. It seems like these structures are actually the smallest ones obtainable in a sensible fashion. OK, one can make a cube-like molecule smaller than with DNA, such as cubane, but with DNA one has a huge toolbox for creating almost any kind of structure. The future will tell if any of these structures are actually useful or not…
- Nilsen1997
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Dendritic Nucleic Acid Structures
Nilsen, T. W. and Grayzel, J. and Prensky, W.
Journal of Theoretical Biology 187 273-284 (1997)
- Rothemund2004
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Algorithmic Self-Assembly of DNA Sierpinski Triangles
Rothemund, P. W. K. and Papadakis, N. and Winfree, E.
PLOS Biology 2 2041-2054 (2004)
10.1371/journal.pbio.0020424
- Liu2000
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DNA Nanotubes: Construction and Characterization of Filaments Composed of TX -tile Lattice
Liu, D. and Reif, J. H. and LaBean, T. H.
(2000)
- Simmel2005
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DNA Nanodevices
Simmel, F. C. and Dittmer, W. U.
Small 1 284-299 (2005)
10.1002/smll.200400111
- Feldkamp2006
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Rationaler Entwurf von DNA-Nanoarchitekturen / Rational Design of DNA Nanoarchitectures
Feldkamp, U. and Niemeyer, C. M.
Angewandte Chemie 118 1888-1910 (2006)
10.1002/ange.200502358 (german) 10.1002/anie.200502358 (english)
These all sounds good but the DNA techniques are too biology-oriented for a traditional chemistry lab to acquire.
Andrew, admit it: a traditional chemistry lab will never even want to do this! If you play with DNA, you are actually playing on a supramolecular level that is never in the range of traditional chemistry labs.
Seriously: as long as longer DNA-molecules can only be prepared either with special robots or via biological methods (and I don’t see this changing any time soon) this is where things will happen. And as such far away from traditional chemistry.
Even though most biologists or biochemists would probably not feel comfortable at that level. So that leaves them in the same boat with those chemists…